關(guān)于舉辦美國馬里蘭大學(xué)宋九州教授報(bào)告會的通知
報(bào) 告 人：宋九州（美國馬里蘭大學(xué)教授）
報(bào)告題目: Evaluation of Clustering Analysis and Term-tissue specific models for Temporal Gene Expression Data with PCA Test and SVM
時(shí) 間：2009年1月4日（星期天）下午3：00
地 點(diǎn)：理學(xué)院二樓多媒體教室
報(bào)告內(nèi)容摘要: Predictive classification on the base of gene expression profiles appeared recently as an attractive strategy for identifying the biological functions of genes. Gene Ontology (GO) provides a valuable source of knowledge for model training and validation. The increasing collection of microarray data represents a valuable source for generating functional hypotheses of uncharacterized genes. This study focused on using support vector machines (SVM) to predict GO biological processes from individual or multiple-tissue transcriptional profiles of aging in Drosophila melanogaster. Ten-fold cross validation was implemented to evaluate the prediction. One-tail Fisher’s exact test was conducted on each cross validation and multiple testing was addressed using BH FDR procedure. The results showed that, of the 148 pursued GO biological processes, fifteen terms each had at least one model with FDR-adjusted p-value (Adj.p) <0.05 and six had the values between 0.05 and 0.25. Furthermore, all these models had the prediction sensitivity (SN) over 30% and specificity (SP) over 80%. We proposed the concept of term-tissue specific models indicating the fact that the major part of the optimized prediction models was trained from individual tissue data. Furthermore, we observed that the memberships of the genes involved in all the three pursued children biological processes on mitochondrial electron transport could be predicted from the transcriptional profiles of aging (Adj.p < 0.01). This finding may be important in biology because the genes of mitochondria play a critical role in the longevity of C. elegans and D. melanogaster.
個(gè)人簡歷
宋九州博士，美國馬里蘭大學(xué)農(nóng)業(yè)與自然資源學(xué)院動(dòng)物與禽類科學(xué)系教授，目前主要從事生物統(tǒng)計(jì),，統(tǒng)計(jì)基因組,，生物信息學(xué)和基因網(wǎng)絡(luò)等生物領(lǐng)域的科學(xué)研究,。近五年發(fā)表高質(zhì)量的論文十余篇,。2005至現(xiàn)在：任American Society of Mathematical Biology 和International Society of Animal Genetics 委員，2007至現(xiàn)在：任American Biological Safety Association 委員,。
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理學(xué)院
二零零八年十二月三十一日